Paramedics have taken six people to hospital from the scene, near the corner of Centre Rd and Clayton Rd, including the driver of the car.
No one is in a critical condition, but CCTV footage shows the car travelling at speed along the footpath, destroying chairs and tables out the front of a cafe.
Ambulance Victoria arrived at the scene minutes after the 12.25pm incident and treated the injured, including a teenage girl, a woman in her 30s, a man in his 30s, and a man in his 40s â€" who were treated for leg pain.
Another man, aged in his 70s, suffered chest pains while a woman in her 40s was distressed.
All were taken to the Monash Medical Centre and are in a stable condition.
Victoria Police say it is believed that a man mistook driving the car mistook the accelerator for the brake.
The driver, and sole occupant, then lost control of the vehicle causing the car to strike a parked car before mounting the footpath on Clayton Road.
The car then travelled along the footpath for a distance, before colliding with a wall of a business.
A 74-year-old Clayton South man was among those conveyed to hospital with minor injuries.
The investigation is ongoing.
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